Combinatorial cancer immunotherapy strategies with proapoptotic small-molecule IAP antagonists
نویسندگان
چکیده
منابع مشابه
Small-molecule IAP antagonists sensitize cancer cells to TRAIL-induced apoptosis: roles of XIAP and cIAPs.
TNF-related apoptosis-inducing ligand (TRAIL) is a promising anticancer agent because it shows apoptosis-inducing activity in transformed, but not in normal, cells. As with most anticancer agents, however, its clinical use is restricted by either inherent or acquired resistance by cancer cells. We demonstrate here that small-molecule SMAC mimetics that antagonize the inhibitor of apoptosis prot...
متن کاملSmall-molecule Bcl-2 Antagonists
Dynamic protein–protein interactions between proapoptotic and pro-survival Bcl-2 family members regulate outer-mitochondrial membrane permeabilization and cytochrome c release, key events in the path to apoptosis. Their relative levels often dictate the fate of a cell following an apoptotic stimulus. However, in cancer cells, the pro-survival Bcl-2 family members are frequently upregulated, the...
متن کاملA novel combinatorial cancer immunotherapy
Author's View CD8 + cytotoxic T lymphocytes (CTLs) are the most efficient mediators of the adaptive immune system. Among the myriad of immune cell responses to cancer, CTLs are capable of both recognizing and destroying tumor cells. CTLs recognize antigens on the surface of tumor cells that are presented as MHC class I-peptide complexes. These peptides, known as CTL epitopes, are commonly deriv...
متن کاملSmall molecule antagonists of melanopsin-mediated phototransduction
Melanopsin, expressed in a subset of retinal ganglion cells, mediates behavioral adaptation to ambient light and other non-image-forming photic responses. This has raised the possibility that pharmacological manipulation of melanopsin can modulate several central nervous system responses, including photophobia, sleep, circadian rhythms and neuroendocrine function. Here we describe the identific...
متن کاملDiscovery of small molecule CXCR4 antagonists.
In light of a proposed molecular mechanism for the C-X-C chemokine receptor type 4 (CXCR4) antagonist 1 (AMD3100), a template with the general structure 2 was designed, and 15 was identified as a lead by means of an affinity binding assay against the ligand-mimicking CXCR4 antagonist 3 (TN14003). Following a structure-activity profile around 15, the design and synthesis of a series of novel sma...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: The International Journal of Developmental Biology
سال: 2015
ISSN: 0214-6282
DOI: 10.1387/ijdb.150084el